Check and Try this link, it might help: http://consumerdocs.installshield.com/selfservice/viewContent.do?externalId=Q108497&sliceId=1 Example: Q: I'm having a problem installing The Powerpuff Girls game. The installer starts and then tells me "The InstallShield Engine (iKernel.exe) could not be launched. No such interface supported". A: This error appears on some systems and is caused by a bug in the Installshield software. In most cases, the installation can be completed by deleting the folder C:\Program Files\Common Files\InstallShield\Engine. After deleting this folder, clear it from the recycle bin (empty the recycle bin), and restart the installation. http://www.annoyances.org/exec/forum/winxp/t1064933406 if the app is not compatible, we cannot do anything if its an OS issue, then it should be problem with ikernel.exe and install shield check and try these options.